NFL Week 4 picks, predictions, schedule, odds, fantasy tips

Week 4 of the 2026 NFL season is right here. We’ll get a variety of spectacular QB duels this week, as Joe Burrow faces Trevor Lawrence, Drake Maye and Josh Allen go head-to-head, and Matthew Stafford challenges Jalen Hurts. This week will even convey intra-division showdowns between the Chiefs and Raiders and an NFC South matchup Monday.

We’re right here to get you prepared for the motion. First, our NFL Nation reporters take you contained in the locker room with one of the best factor they heard this week, and ESPN Research offers a key stat to know. Then, analytics author Seth Walder makes a daring prediction for every matchup, NFL analyst Ben Solak provides one purpose to tune into every sport, fantasy analyst Eric Moody shares fantasy football intel and betting analyst Pamela Maldonado hits betting insights for every contest. We even have Football Power Index (FPI) sport projections, and Maldonado, Moody and Walder all give us last rating picks for each sport.

Let’s get into the complete Week 4 slate, which culminates with a “Monday Night Football” matchup between the Falcons and Saints on ESPN. (Game occasions are Sunday until in any other case famous, and all odds are by way of DraftKings.)

Jump to a matchup:
IND-WSH | JAX-CIN | DAL-HOU
NE-BUF | LAR-PHI | NYJ-CHI
TEN-BAL | GB-TB | ARI-NYG
MIA-MIN | DEN-SF | LAC-SEA
KC-LV | DET-CAR | ATL-NO

Thursday: PIT-CLE

What ESPN Analytics says …

9:30 a.m. ET | NFL Network | IND -3.5 (47.5 O/U)

What we’re listening to on the Colts: QB Daniel Jones is on tempo for one of many lowest yards-per-attempt marks of his profession, with a present common of 6.2. But that is most likely much less about Jones’ efficiency and extra a mirrored image of what the Colts appear like with out WR Alec Pierce (heel). Pierce is predicted to sit down out a number of weeks, forcing the Colts to search out artistic methods to generate massive performs, which has been tough. Look for new acquisition Darius Slayton to make his debut at receiver. — Stephen Holder

What we’re listening to on the Commanders: Washington’s run protection ranks third in yards allowed and Twelfth in yards per carry. When it is simply together with RBs, the Commanders are sixth in yards per carry and first in fewest positive factors of 10-plus yards. Now they face Jonathan Taylor, who has averaged 4.9 yards per carry in his profession however has a league-high 27 carries of 1 yard or fewer. “[Taylor] has game-breaking speed, he’s physical,” defensive coordinator Daronte Jones mentioned. The Commanders’ run protection has been keyed by their entrance seven. DT Daron Payne mentioned it is nearly “being real physical and dominating the line.” — John Keim

Stat to know: The Colts’ protection is giving up 417.3 whole yards per sport — essentially the most within the NFL. — ESPN Research

Bold prediction: Commanders WR Stefon Diggs will report no less than 85 receiving yards. So far, Diggs’ season excessive is 55 yards. He has posted a stable 1.8 yards per route run this season, however the truth that he’s being focused on 33% of his routes suggests his manufacturing may very well be even stronger going ahead. — Walder

Why you must watch this sport: You do not want a purpose to look at the London sport — it is the one sport on at the moment, and an incredible appetizer whilst you’re toasting your bagels and brewing your espresso. — Solak

Injuries: Colts | Commanders

Fantasy nugget: Commanders QB Marcus Mariota completed with 20.4 fantasy factors towards a stout Seahawks protection in Week 3 and now faces a Colts protection that has allowed the fifth-most fantasy factors to QBs. This matchup units up properly for Mariota and his No. 1 receiver, Terry McLaurin. See Week 4 rankings. — Moody

Betting perception: Overs are 7-2 in Mariota’s begins for the reason that begin of final season. I like that pattern to proceed, as each QBs have openings right here. Washington struggles towards play-action, giving Jones and TE Tyler Warren a good matchup. Meanwhile, Indianapolis has given up 30.3 factors per sport and Diggs can exploit its slot protection. Mariota can maintain Washington scoring. Read more. — Maldonado

Maldonado’s decide: Colts 27, Commanders 24
Moody’s decide: Colts 31, Commanders 23
Walder’s decide: Colts 23, Commanders 19
FPI prediction: IND, 54.4% (by a median of 1.3 factors)

Matchup must-reads: Injured in warmups, Shrader rallies Colts with FG … Daniels not worried about re-injuring elbow: ‘That’s what the brace is for’ … London game remind Mariota of football-soccer connection

1 p.m. ET | CBS | CIN -2.5 (51.5 O/U)

What we’re listening to on the Jaguars: Cincinnati is the one AFC crew that QB Trevor Lawrence hasn’t overwhelmed. He’s 0-3 towards the Bengals however has put up good numbers towards them: 66% completion charge, 733 passing yards, 5 landing passes and solely two interceptions. Lawrence mentioned he did not know he was winless within the collection: “You don’t really think about that,” he mentioned. — Michael DiRocco

What we’re listening to on the Bengals: All eyes will likely be on the matchup between Cincinnati CB Dax Hill and Jacksonville WR Parker Washington. Hill strikes into the slot after an damage to Jalen Davis (hamstring). Washington has seven catches for 108 yards and two touchdowns whereas within the slot this season. Hill has expertise in that function and can must be stable as he transitions again inside. — Ben Baby

Stat to know: After his three-touchdown efficiency towards Pittsburgh final week, Bengals QB Joe Burrow comes into this sport with 28 video games with three or extra passing TDs since 2021 (most within the NFL). — ESPN Research

Bold prediction: Jaguars edge Travon Walker will report no multiple go rush win. That’s as a result of Walker will likely be dealing with proper deal with Amarius Mims, who’s off to a scorching begin with a 92.9% go block win charge, which ranks third amongst all tackles. — Walder

Why you must watch this sport: We have a possible Travis Hunter versus Ja’Marr Chase matchup when the Bengals have the ball — these are two of one of the best fluid movers within the league towards one another. This additionally is perhaps a playoff preview. — Solak

Injuries: Jaguars | Bengals

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J.J. McCarthy involves Giants as a backup QB

Fantasy nugget: Washington has earned no less than 5 targets and 13 fantasy factors in each sport this season. Cincinnati’s protection leads the league in yards after catch allowed and has the fourth-most missed tackles, which units up properly for a Jaguars offense that has scored touchdowns on 8.6% of its go makes an attempt. See Week 4 rankings. — Moody

Betting perception: The Jaguars are 6-3 to the over on the highway since final season. That will proceed as a result of Burrow will get the ball out shortly, limiting Jacksonville’s probabilities to stress him and exposing its protection. Lawrence can reply towards a Bengals protection that provides up simple yards on first down, with a aggressive sport conserving each QBs throwing into the fourth quarter. Read more. — Maldonado

Maldonado’s decide: Bengals 30, Jaguars 27
Moody’s decide: Jaguars 34, Bengals 31
Walder’s decide: Bengals 27, Jaguars 24
FPI prediction: JAX, 54.6% (by a median of 1.1 factors)

Matchup must-reads: Tracking Travis: Are the Jaguars really playing Hunter on both offense and defense? … Bengals cut WR Williams after costly muffed punt

1 p.m. ET | Fox | HOU -3 (48.5 O/U)

What we’re listening to on the Cowboys: The Cowboys are doing their finest to maneuver on from a heartbreaking loss to Baltimore and the 10-hour flight dwelling from Rio de Janeiro that affected their preparation this week. At 1-2, defensive deal with Kenny Clark mentioned, “We need this win too, so we need to be more desperate.” Since 2000, the Cowboys have opened the season with one win of their first 4 video games 4 occasions (2025, 2020, 2010, 2000) and didn’t end any of these seasons with a successful report. “We feel like this is going to turn, and it’s going to turn, and when it does,” coach Brian Schottenheimer mentioned, “I think we’ll be a tough match.” — Todd Archer

What we’re listening to on the Texans: It is actually do-or-die for the Texans. But fortunately for them, they more than likely will get again star wideout Nico Collins. Collins has been out for 2 weeks because of a hamstring injury, however he practiced Wednesday and Thursday. That is a promising signal for an offense that averaged 11.5 factors with out him. — DJ Bien-Aime

Stat to know: Cowboys QB Dak Prescott has a 31.2 whole QBR in two profession begins towards the Texans, his second-lowest whole QBR towards a single opponent, forward of solely the Colts (29.6). — ESPN Research

Bold prediction: Texans QB C.J. Stroud will go for 300 or extra yards. The Cowboys’ protection ranks thirty first in EPA allowed per dropback, and the Texans have struggled to run the ball this season. I anticipate they’re going to wish to let Stroud throw all day. — Walder

Why you must watch this sport: This is a desperation bowl between the Cowboys and Texans. Since 1990, 1-3 groups have made the playoffs solely 14.3% of the time, in response to ESPN Research. Don’t even ask me what historical past says about 0-4 groups. — Solak

Injuries: Cowboys | Texans

Fantasy nugget: Houston has given up the second-most fantasy factors per sport to WRs, and its defensive entrance ranks thirtieth in go rush win charge. That ought to give Prescott time to get the ball to WRs CeeDee Lamb and George Pickens. Jake Ferguson can also be in a great spot towards a Texans protection giving up the fourth-most receiving yards per sport to TEs. See Week 4 rankings. — Moody

Betting perception: The Texans are 0-3 ATS (towards the unfold) this season, all in video games with traces between +3 and -3. That ought to proceed towards Dallas as a result of Houston’s safety issues and ineffective dashing assault make separation tough. Prescott and Lamb give the Cowboys a reliable connection to use Houston’s third-down vulnerabilities, conserving Dallas throughout the quantity even when the Texans’ go rush disrupts drives. Read more. — Maldonado

Maldonado’s decide: Cowboys 24, Texans 23
Moody’s decide: Cowboys 23, Texans 19
Walder’s decide: Texans 27, Cowboys 26
FPI prediction: DAL, 54.3% (by a median of 1.3 factors)

Matchup must-reads: Why Steelers traded Porter to Cowboys, what’s next? … Can the 0-3 Texans defy history again to make playoffs? … This one hurts’: How are Cowboys reacting to third straight 1-2 start?

1 p.m. ET | CBS | BUF -6.5 (48.5 O/U)

What we’re listening to on the Patriots: Coach Mike Vrabel identified that the Bills have solely 5 punts of their 3-0 begin, which he cited for example of how difficult it may be dealing with QB Josh Allen. Vrabel additionally shined the highlight on an usually ignored group: the Bills’ offensive line of LT Dion Dawkins, LG Alec Anderson, C Connor McGovern, RG O’Cyrus Torrence and RT Spencer Brown. “The linemen do a fantastic job of understanding the scheme that they want to run and creating lanes for [James] Cook, who, once he gets cooking — no pun intended — they’re just tough to stop,” he mentioned. — Mike Reiss

What we’re listening to on the Bills: After CB Christian Benford exited final Sunday’s sport due to a toe damage, rookie Davison Igbinosun impressed with 5 tackles, a go breakup and a QB hurry. DC Jim Leonhard prioritized giving rookies rotational reps within the first two weeks so that they’d be ready and undaunted when massive alternatives landed of their laps. With Benford persevering with to cope with the damage, Igbinosun might get an extended look towards the Patriots, and coach Joe Brady is welcoming the chance: “There’ll never be a moment when I’m the head football coach where there’s 11 guys on the field that I’m not going to be confident in them.” — Nick Suss

Stat to know: Allen is the fourth participant in NFL historical past with two or extra dashing touchdowns in three straight video games to begin a season (1958 Jim Brown, 1999 Stephen Davis and 2003 Priest Holmes). — ESPN Research

Bold prediction: Patriots edge Elijah Ponder will report a sack. Ponder has been a vivid spot in New England’s powerful season, with 24% go rush win charge that ranks seventeenth at edge. With Harold Landry III on the bodily unable to carry out record, and Dre’Mont Jones sitting out final week’s sport due to a shoulder damage, Ponder turns into that rather more essential for New England. — Walder

Why you must watch this sport: Divisional clashes are all the time enjoyable, even when one crew is reeling the way in which the Patriots are. Plus, edge rusher Greg Rousseau can also be seeking to grow to be solely the fourth participant in NFL historical past with 4 consecutive video games of two or extra sacks. — Solak

Injuries: Patriots | Bills

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Fantasy nugget: Mack Hollins led Patriots receivers in targets (9) and fantasy factors (14.7) in Week 3. QB Drake Maye has struggled, failing to attain greater than 9.8 fantasy factors in any sport this season. New England is an underdog, which might result in extra passing quantity, and Hollins attracts a Bills protection that has allowed the fifth-most fantasy factors per sport to WRs. See Week 4 rankings. — Moody

Betting perception: All three Patriots video games have gone beneath the overall with the biggest beneath margin of any NFL crew. Maye’s turnovers and struggles on third down maintain killing drives. New England additionally provides up the fewest yards per drive, and its aggressive blitzing might take a look at Allen’s mobility after his knee damage. I anticipate Buffalo to lean on Cook, conserving this sport low-scoring. Read more. — Maldonado

Maldonado’s decide: Bills 27, Patriots 17
Moody’s decide: Bills 30, Patriots 27
Walder’s decide: Bills 24, Patriots 20
FPI prediction: BUF, 70.5% (by a median of 5.6 factors)

Matchup must-reads: What has gone wrong for the Patriots’ offense, Maye? … Rousseau’s sacks, Allen’s rushing TDs are on record paces for Bills

1 p.m. ET | Fox | LAR -3 (43.5 O/U)

What we’re listening to on the Rams: Rams DT Aaron Donald has performed 56% of defensive snaps within the two video games he has performed this season, and in response to ESPN Analytics/NFL Next Gen Stats, his 33% go rush win charge as inside defender is the second highest in NFL. Donald didn’t apply Wednesday, as he’s coping with a sore again, coach Sean McVay mentioned. McVay mentioned the crew was “taking it a day at a time” with Donald’s standing for Week 4. — Sarah Barshop

What we’re listening to on the Eagles: The protection is off to a slower begin than anticipated, partially as a result of it has but to generate a turnover. It’s the primary time in franchise historical past the Eagles have been blanked over the primary three weeks of the season and they’re now the one crew in NFL with no takeaway. Ball drills will likely be a part of the main focus this week to attempt to flip go breakups into interceptions. “Coaches throwing ball drills is almost a waste because they’re lollipops,” DC Vic Fangio mentioned. “We’ve got to get them on the jugs or get a real quarterbacks throwing them some balls that have some RPMs, maybe like a [Phillies closer Jhoan] Duran fastball reasonably than a Jamie Moyer.” — Tim McManus

Stat to know: In NFL historical past, no crew with no takeaway within the first 4 weeks has had a successful report. — ESPN Research

Bold prediction: Rams RB Blake Corum will rush for 90 or extra yards. This is largely as a result of I’m predicting a runaway win for Los Angeles, and that ought to give extra alternative for Corum. But additionally, the Eagles’ protection ranks solely twenty second in EPA allowed per designed run to date this season. — Walder

Why you must watch this sport: Rams WR Puka Nacua is again and urgently wanted. And this 1-2 Rams crew is searching for revenge after last season’s game between the groups ended on a blocked discipline aim try returned for a landing. — Solak

Injuries: Rams | Eagles

Fantasy nugget: Eagles RB Saquon Barkley has been held beneath 10 fantasy factors in three consecutive video games for the primary time in his profession. He additionally has but to surpass 15 dashing makes an attempt in a sport. The Rams’ defensive entrance ranks eighth in run cease win charge, so this may very well be one other powerful matchup for the Eagles’ offensive line and working sport. See Week 4 rankings. — Moody

Betting perception: The Eagles are 0-5 outright and 1-4 ATS as dwelling underdogs beneath coach Nick Sirianni. Philadelphia’s offense retains getting caught on third downs. whereas the Rams persistently transfer the ball on early downs. Los Angeles additionally generates stress regardless of its low sack whole, which might create issues for QB Jalen Hurts behind an injured line. Matthew Stafford is a harder problem than the QBs Philadelphia has just lately confronted. Read more. — Maldonado

Maldonado’s decide: Rams 24, Eagles 20
Moody’s decide: Rams 37, Eagles 26
Walder’s decide: Rams 27, Eagles 14
FPI prediction: LAR, 64.3% (by a median of three.8 factors)

Matchup must-reads: Have the Rams improved special teams enough to make a difference? … Sirianni regrets reaction to hit on QB Hurts in Eagles’ loss

1 p.m. ET | Fox | CHI -3.5 (43.5 O/U)

What we’re listening to on the Jets: RB Breece Hall (quad), WR Adonai Mitchell (finger) and TE Mason Taylor (thumb) will not be anticipated to play. So the Jets will lean closely on QB Geno Smith, who’s coming off the most effective statistical video games of his profession. Ball safety will likely be paramount. Smith, who led the NFL with 17 interceptions final season, has but to throw a decide. But he’ll face an opportunistic protection. Since the beginning of final season, the Bears have eight video games with three-plus takeaways, most within the NFL. — Rich Cimini

What we’re listening to on the Bears: Kalif Raymond is the Bears’ main receiver by three video games (214 yards) and is averaging 2.8 yards per route (ninth finest amongst WRs with no less than 50 routes). Only one in all his targets have been beneath 20 air yards as he continues to determine himself because the go-to deep risk for Bears QBs, recording 186 receiving yards and 105 yards after the catch on these throws. “He’s a clinic tape,” OC Press Taylor mentioned. “If there’s a route on air, he’s going to run it exactly the way you want, and then it carries over to a game, and he’s going to run exactly the way you want.” — Courtney Cronin

Stat to know: The Jets have suffered one-score losses (determined by eight factors or fewer) in every of previous two video games. New York is 3-7 in one-score video games beneath coach Aaron Glenn, which is tied for fourth worst. — ESPN Research

Bold prediction: The Jets will catch a number of touchdowns towards CB Jaylon Johnson. He has allowed 2.4 yards per protection snap this season, per NFL Next Gen Stats, by far the worst amongst all outdoors CBs with no less than 75 protection snaps this season. — Walder

Why you must watch this sport: It’s Glenn versus Ben Johnson within the battle of vaunted ex-Lions coordinators. The Bears have been magical on offense last week — let’s have a look at if Tyson Bagent or Case Keenum can maintain it going. — Solak

Injuries: Jets | Bears

Fantasy nugget: The Bears’ defensive entrance ranks final within the league in run cease win charge and has given up the Twelfth-most dashing yards per sport this season. Chicago’s secondary has been significantly better, particularly over the previous two video games. Even with Smith coming off a 24-point fantasy efficiency towards Detroit, the Jets might lean extra closely on the run on this matchup. See Week 4 rankings. — Moody

Betting perception: The Jets are 8-5-1 ATS beneath Glenn when not getting no less than seven factors. Smith will get a protection that blitzes usually and performs single-high protection, two seems to be he has dealt with properly, which ought to create alternatives for WR Garrett Wilson. With Chicago doubtlessly beginning Bagent at QB, I belief Smith to maintain this shut sufficient for New York to be aggressive. Read more. — Maldonado

Maldonado’s decide: Bears 23, Jets 20
Moody’s decide: Bears 23, Jets 20
Walder’s decide: Bears 30, Jets 27
FPI prediction: CHI, 62.5% (by a median of three.3 factors)

Matchup must-reads: Why QB Smith’s hot start has been a bright spot for the Jets … Bears’ Johnson: ‘Direction already made’ on Week 4 QB call

1 p.m. ET | CBS | BAL -11.5 (42.5 O/U)

What we’re listening to on the Titans: Obviously the entire consideration will likely be on RB Derrick Henry, the previous face of the franchise. But the Titans are ready for QB Cam Ward to be their subsequent featured participant. Ward has struggled and threw his first interception of the season to wrap up final week’s loss. Ward confirmed he is able to shifting the offense, however the Titans need to do it extra steadily in the event that they plan to compete with the Ravens. “We saw a glimpse of it in the second half last week where we had three really, really long drives where we looked efficient,” coach Robert Saleh mentioned. — Turron Davenport

What we’re listening to on the Ravens: Tackling will likely be a significant component in how Henry fares in his first sport towards his former crew. This season, Henry has gained 138 dashing yards after first contact, which is the third most within the NFL. The Titans have given up 220 dashing yards after contact, which is the third worst within the league. “It’s still like family there, so it’s always love,” Henry mentioned, “but it’s not going to be much love on Sunday though.” — Jamison Hensley

Stat to know: The Titans are averaging 12.3 factors, which is the second-worst mark this season (Patriots and Dolphins each common 12.0). — ESPN Research

Bold prediction: Henry will report no less than 40 receiving yards. The Titans play a really zone-heavy protection, which inspires extra RB receptions. And although Henry is not recognized for his receiving prowess, when he does catch passes, they have an inclination to lead to important chunks of yards. — Walder

Why you must watch this sport: Henry is dealing with the Titans for the primary time in his profession. How might you miss that? — Solak

Injuries: Titans | Ravens

Fantasy nugget: The Titans have given up the ninth-most dashing yards per sport this season, so Baltimore might lean closely on Henry behind an offensive line that ranks third in run block win charge. Mark Andrews is a little bit harder to belief in lineups. Tennessee has given up the third-fewest fantasy factors per sport to TEs and hasn’t given up a receiving landing to the place. See Week 4 rankings. — Moody

Betting perception: Double-digit dwelling favorites are 28-16 ATS over the previous three seasons and 1-0 ATS this season. Baltimore can maintain the ball shifting with QB Lamar Jackson and Henry creating massive positive factors earlier than third down. Tennessee punts on practically 60% of possessions, which ought to give the Ravens repeated probabilities to tug away. Ward’s struggles provide little purpose to anticipate a late comeback. Read more. — Maldonado

Maldonado’s decide: Ravens 27, Titans 13
Moody’s decide: Ravens 28, Titans 19
Walder’s decide: Ravens 34, Titans 20
FPI prediction: BAL, 83.8% (by a median of 10.4 factors)

Matchup must-reads: Ravens’ Henry: ‘Always love’ for Titans, but not much this Sunday … QB Jackson, Ravens looking for first home win since before Thanksgiving … Titans, Henry going in opposite directions

1 p.m. ET | Fox | GB -3.5 (38.5 O/U)

What we’re listening to on the Packers: Guard Kevin Zeitler‘s first time at Lambeau Field was not a pleasing one. The Milwaukee-area native was invited to a dinner honoring all-state highschool gamers. “Unfortunately got severe food poisoning from it,” Zeitler mentioned. More than 18 years later, he is again in Green Bay as a part of an overhaul of the Packers’ offensive line this week. They not solely signed Zeitler but in addition fellow previous first-round picks Laken Tomlinson and Mekhi Becton (apply squad) in an effort to show round what has been the worst blocking unit within the NFL. It’s not out of the query that no less than one of many newcomers begins Sunday. — Rob Demovsky

What we’re listening to on the Buccaneers: Preparing to make his first NFL begin instead of injured Baker Mayfield (thumb), undrafted rookie Jalon Daniels mentioned of taking over this huge process: (*4*) — Jenna Laine

Stat to know: Packers WR Matthew Golden has 253 receiving yards to begin this season (eighth most within the NFL). He wants 109 extra yards to surpass his whole of 361 throughout 14 video games throughout his rookie season final yr. — ESPN Research

Bold prediction: Daniels will report a 70-plus QBR. I’ve irrational perception in Daniels, stemming from watching him within the preseason and the truth that an undrafted free agent like him must go above and past to win the backup QB job. I like his probabilities in his beginning debut. — Walder

Why you must watch this sport: The final rookie undrafted free agent QB to begin for his crew this early in an NFL season was Tyson Bagent in Week 7 of the 2023 season. Now it is Daniels’ flip. Is {that a} purpose to look at? Well, it is one of the best I’ve. — Solak

Injuries: Packers | Buccaneers

Fantasy nugget: Bucs RB Bucky Irving has had no less than 15 touches in three consecutive video games. The Buccaneers might lean extra on the working sport with Daniels set to begin. Green Bay has given up the second-most fantasy factors per sport to RBs, so this units up as a good matchup for Irving. The Packers gave up 35.3 fantasy factors to Falcons’ Bijan Robinson final week. See Week 4 rankings. — Moody

Betting perception: Packers QB Jordan Love is 0-9 ATS when laying no less than three factors on the highway. Green Bay cannot run the ball and its struggling offensive line leaves Love beneath fixed stress. Tampa Bay’s aggressive blitzing can disrupt drives, and its stout run protection retains all the things on Love. Even towards a rookie QB, these Packers are powerful to belief. Read more. — Maldonado

Maldonado’s decide: Packers 20, Buccaneers 17
Moody’s decide: Packers 24, Buccaneers 17
Walder’s decide: Buccaneers 23, Packers 20
FPI prediction: GB, 67.3% (by a median of 4.6 factors)

Matchup must-reads: Packers’ O-line leaves QB Love under constant pressure … Buccaneers’ QB Mayfield (thumb) out at least three weeks, Bowles says

1 p.m. ET | CBS | ARI -2.5 (44.5 O/U)

What we’re listening to on the Cardinals: Arizona hopes that is the week it will probably get its downfield passing sport going. The Cardinals have the fewest quantity of performs of 20 yards or longer within the NFL, due partially to their first three opponents enjoying the very best charge of Cover 2 and zone towards them in comparison with the complete league. That has prevented Arizona from going excessive, and QB Jacoby Brissett mentioned this additionally disrupts the Cardinals’ timing. But WR Marvin Harrison Jr. says he expects the Giants to play extra man protection on the line of scrimmage, which might spring Arizona’s downfield offense. — Josh Weinfuss

What we’re listening to on the Giants: The Giants appear to know they are not dealing with the Titans’ offense once more this week. It was talked about a number of occasions that the Cardinals are “very similar” offensively to the Rams — who dismantled the Giants two weeks in the past — which DC Dennard Wilson famous due to Arizona coach Mike LaFleur’s ties to Sean McVay. New York is aware of it’ll be a tough problem, significantly stopping rookie RB Jeremiyah Love, who it had ranked as a top-three participant within the 2026 draft. — Jordan Raanan

Stat to know: Cardinals TE Trey McBride has had 9 video games with 50 receiving yards and no less than one landing reception for the reason that begin of final season, tied with Lions’ Amon-Ra St. Brown for the second most amongst all gamers (Seahawks’ Jaxon Smith-Njigba, 11). — ESPN Research

Bold prediction: The Giants’ newly acquired backup QB, J.J. McCarthy, will enter late in a blowout loss. Jameis Winston has been very uninspiring enjoying in Jaxson Dart‘s stead, and I do not purchase the notion that the Giants dealt a fifth-round decide for McCarthy to solely be a third-stringer. — Walder

Why you must watch this sport: With the Giants’ acquisition of McCarthy, any Winston begin is perhaps his final of the season. And that is value a watch. — Solak

Injuries: Cardinals | Giants

Fantasy nugget: Love completed Week 3 with season highs in touches (26) and fantasy factors (21.9). The Cardinals haven’t got a powerful offensive line, however they may face a defensive entrance that ranks twenty seventh in run cease win charge. This season, New York has given up 24.2 fantasy factors to Cowboys’ Javonte Williams, 15.7 to Rams’ Kyren Williams and 13.6 to Titans’ Tony Pollard. See Week 4 rankings. — Moody

Betting perception: The Cardinals haven’t been favored on the highway since Week 1 final season, however this matchup justifies it. Without edge rusher Brian Burns (knee), New York’s league-worst stress charge will give Brissett time to search out McBride beneath and maintain drives. Winston’s accuracy struggles ought to restrict the Giants’ response, giving Arizona the steadier passing offense and the sting to cowl this unfold. Read more. — Maldonado

Maldonado’s decide: Cardinals 20, Giants 17
Moody’s decide: Cardinals 20, Giants 13
Walder’s decide: Cardinals 29, Giants 6
FPI prediction: ARI, 54.2% (by a median of 1.2 factors)

Matchup must-reads: Cardinals rookie RB Love earns bigger role in offense … Giants’ Harbaugh explains reasoning for releasing Beckham

4:05 p.m. ET | Fox | MIN -10.5 (38.5 O/U)

What we’re listening to on the Dolphins: Dolphins RB Ollie Gordon II dealt with a 20-touch workload as soon as De’Von Achane (knee) went down in Week 3, however that is not essentially a sign of what his function will likely be shifting ahead. Fellow RB Jaylen Wright mentioned the foot damage that stored him out of final week’s sport has healed, and coach Jeff Hafley says he nonetheless needs his crew to run the ball — however he additionally says it is probably the Dolphins make use of a cut up backfield for the foreseeable future. — Marcel Louis-Jacques

What we’re listening to on the Vikings: Five years after being fired because the Dolphins’ coach, Brian Flores is coordinating the NFL’s top-ranked protection by EPA. The Dolphins’ offense ranks No. 27, and because the crew strikes ahead with out Achane, the chance exists for Flores to embarrass the crew he stays in litigation against. But Flores mentioned this week that “I’m actually excited to see some people,” earlier than naming a collection of soccer operations staffers who stay from his tenure. “I’m the same every week,” Flores mentioned. “It’s never about me. It’s always about the team.” — Kevin Seifert

Stat to know: The Vikings blitz on 68.4% of opponent dropbacks, greater than 20% larger than some other crew within the NFL (Commanders, 46.6%). That is on tempo to be the very best by any crew in a season since ESPN started monitoring blitzes in 2006. — ESPN Research

Bold prediction: The Dolphins will win the sport. Minnesota recorded solely a 16% success charge on dropbacks final week in QB Kyler Murray‘s return, third worst amongst all video games for the reason that begin of 2025. Miami is a big lengthy shot, however I ponder if a brilliant run-heavy strategy and continued offensive struggles from the Vikings might earn the Dolphins a victory. — Walder

Why you must watch this sport: The finest counterattack to a Flores protection is perhaps a QB with elite escapability — and that is Malik Willis. This can also be Flores’ first time dealing with his previous crew, the Dolphins, as DC of the Vikings. This is perhaps a type of video games that you could inform issues just a bit extra. — Solak

Injuries: Dolphins | Vikings

Fantasy nugget: Vikings tight finish T.J. Hockenson faces a Dolphins protection that has given up the fifth-most receiving yards to TEs this season. Josh Oliver (biceps) is on injured reserve, and vast receiver Justin Jefferson is coping with an ankle injury, which might result in extra targets for Hockenson. This season, Miami has given up 26.2 fantasy factors to the 49ers’ George Kittle and 13.9 to the Chiefs’ Travis Kelce. See Week 4 rankings. — Moody

Betting perception: The Vikings have gained eight straight video games with unders, going 6-2 in that span, and that may proceed. Minnesota’s relentless blitzing might overwhelm Willis, who struggles towards stress and has thrown just one landing go this season. Meanwhile, the Vikings nonetheless wrestle to maintain drives alive and end scoring probabilities. Miami’s shaky protection affords assist, however Minnesota can management this sport with no need a shootout. Read more. — Maldonado

Maldonado’s decide: Vikings 27, Dolphins 10
Moody’s decide: Vikings 27, Dolphins 13
Walder’s decide: Dolphins 20, Vikings 17
FPI prediction: MIN, 83.1% (by a median of 10.1 factors)

Matchup must-reads: Achane tears ACL, will miss rest of season … Who takes the blame for QB McCarthy exiting Minnesota as a draft bust?

4:25 p.m. ET | CBS | SF -3 (47.5 O/U)

What we’re listening to on the Broncos: Ask QB Bo Nix in regards to the crew’s behavior of gradual begins this season — the Broncos are final within the league in first-half scoring (3.3 factors per sport) — and he factors to first downs. “Are we getting first downs early in drives? Or are we just going first down, second down, third down?” Nix said. “That’s simply exhausting as an offense.” He’s on to something since the Broncos’ success rate on first down this season — plays of at least four yards — is 31.5%. Only the 0-3 Dolphins have been worse. The Broncos probably can’t afford to continue to tempt fate against a 49ers offense that is second in the league in scoring. — Jeff Legwold

What we’re hearing on the 49ers: The Niners are well aware that the Broncos have a habit of coming from behind in the second half and pulling off one-score wins — Denver is 13-2 in those games over the past two seasons. “Denver is among the finest groups within the league at comeback victories and staying within the battle and staying within the struggle, one-score video games, successful these matchups,” LB Fred Warner mentioned. “Every week, we’re looking for the chance to simply win one sport and it takes all three, 4 hours of that sport, no matter it takes. It’s only one play at a time, one quarter at a time and let the remainder deal with itself.” — Nick Wagoner

Stat to know: Broncos WR Jaylen Waddle has a team-high 23% target share this season, which is the second highest of his career through his team’s first three games of a season (29% in 2022). — ESPN Research

Bold prediction: 49ers RB Christian McCaffrey will record 20-plus rush attempts, blowing away his season-high of 15. The 49ers have been the pass-heaviest team in the league in terms of pass rate over expectation (per NFL Next Gen Stats), but I wouldn’t expect them to be that extreme going forward — especially against a Broncos defense that ranks 32nd in EPA allowed per designed carry. — Walder

Why you should watch this game: Huge heat check game for the 49ers, who look like an absolute wagon through three weeks. But they have enjoyed games against the Dolphins and Cardinals, along with their Melbourne win over the sleepy Rams. We’ll learn a lot in this one. — Solak

Injuries: Broncos | 49ers

Fantasy nugget: The 49ers would be wise to lean on McCaffrey and the running game against the Broncos, especially with the injuries they’re dealing with at WR. Denver has given up the fifth-most fantasy points per game to RBs and is tied with the Colts for the third-most receiving yards per game allowed to the position. See Week 4 rankings. — Moody

Betting insight: The Broncos are 9-2 ATS against nonconference opponents since drafting Nix in 2024. Without edge rusher Nick Bosa (calf), San Francisco struggles to pressure QBs, which should give Nix time to settle in and keep drives moving. Denver has held the Chiefs’ Patrick Mahomes, Jaguars’ Trevor Lawrence and Rams’ Matthew Stafford to lower than a 60% completion share, giving its protection an opportunity to gradual QB Brock Purdy. Read more. — Maldonado

Maldonado’s pick: Broncos 27, 49ers 24
Moody’s pick: 49ers 23, Broncos 20
Walder’s pick: 49ers 26, Broncos 20
FPI prediction: SF, 77% (by an average of 7.9 points)

Matchup must-reads: Can the Broncos maintain pulling off unlikely comeback victories? … It’s fun to be doubted’: How Kittle completed his 243-day recovery from torn Achilles … Evans, Williams, Greenlaw don’t have long-term injuries, 49ers say

4:25 p.m. ET | CBS | SEA -7 (42.5 O/U)

What we’re hearing on the Chargers: For the first time in his tenure as Chargers coach, Jim Harbaugh directly critiqued QB Justin Herbert‘s play this week. Harbaugh said Herbert’s decision-making needed to “be higher,” after a Week 3 loss in which Herbert threw an interception but could have had three if it wasn’t for the Bills dropping passes. Herbert echoed Harbaugh’s comments Wednesday, acknowledging he has made bad decisions through the first three weeks. — Kris Rhim

What we’re hearing on the Seahawks: The Chargers rank eighth in yards allowed per rush and EPA per rush on defense. It’s the one thing they’ve done well during their 0-3 start. So the Seahawks aren’t getting a break in that sense after their RBs combined for only 39 yards on 17 attempts in a Week 3 loss. “I feel our guys are working off the rock,” coach Mike Macdonald said of Seattle’s run game. “I feel they’re enjoying arduous. … Sometimes you simply do not get the run sport off the bottom in a sure sport and you do not hit the panic button, you simply return to work and attempt to discover extra options and simply maintain attempting to unravel issues and go attempt to make it higher.” — Brady Henderson

Stat to know: Seahawks WR Jaxon Smith-Njigba has had three straight video games with 100-plus receiving yards and a landing catch, which is tied for second-longest streak to begin a season within the Super Bowl period (since 1966) trailing Randy Moss’ 4 straight (2007). — ESPN Research

Bold prediction: Chargers security Genesis Smith will report one other interception. Last week, he flashed his anticipation and ball abilities by selecting off Josh Allen twice. I say he takes benefit of a QB Sam Darnold mistake in Week 4 to remain scorching. — Walder

Why you must watch this sport: Smith-Njigba is on tempo for two,295 receiving yards. Any sport he is enjoying in is value a watch. — Solak

Injuries: Chargers | Seahawks

Fantasy nugget: Chargers WR Ladd McConkey has had an up-and-down season however nonetheless leads all Chargers playmakers in fantasy factors. Though the Commanders’ Terry McLaurin scored 19.7 fantasy factors towards Seattle final week, the Seahawks have given up the fourth-fewest fantasy factors per sport to WRs. McConkey remains to be a stable possibility, however the matchup limits his upside. See Week 4 rankings. — Moody

Betting perception: Five straight Chargers video games have gone beneath the overall, the longest energetic streak within the NFL. Seattle shuts down the run and provides up the fewest yards per go try, leaving Herbert with out simple solutions. Los Angeles retains stalling drives with false begins and poor ending, and Seattle’s struggling working sport and shaky short-yardage execution must also restrict sustained scoring drives. Read more. — Maldonado

Maldonado’s decide: Seahawks 20, Chargers 17
Moody’s decide: Seahawks 28, Chargers 21
Walder’s decide: Seahawks 26, Chargers 23
FPI prediction: SEA, 74.1% (by a median of 6.8 factors)

Matchup must-reads: Chargers’ Harbaugh on struggling Herbert: ‘Be better’ … Seahawks’ Macdonald says team still believes in RB Price

4:25 p.m. ET | CBS | KC -4.5 (47.5 O/U)

What we’re listening to on the Chiefs: The Chiefs are nonetheless a run-first offense, even with QB Patrick Mahomes. Although RB Kenneth Walker III has been spectacular throughout the Chiefs’ 3-0 begin, OC Eric Bieniemy was capable of finding an space the place the unit can get higher: short-yardage performs. Twice in final week’s win, the Chiefs have been stuffed when giving the ball to Walker and needing lower than a full yard. “We should never get shut down in short-yardage situations,” Bieniemy mentioned. — Nate Taylor

What we’re listening to on the Raiders: If the Raiders wish to have an opportunity to beat the Chiefs and enhance to 4-0, they’re going to want to enhance their run protection. Las Vegas gave up 146 dashing yards towards the Saints final week. And opponents have rushed for 4.6 yards per carry up to now two video games. The Raiders can’t afford to have inconsistencies of their run protection towards Kansas City. Walker has proven big-play skill, with 10 carries of 10-plus yards. “He can hit a home run from anywhere on the field,” coach Klint Kubiak mentioned. — Ryan McFadden

Stat to know: Raiders CB Hezekiah Masses has grabbed three interceptions this season, tied with the Giants’ Jevon Holland for essentially the most by any participant within the NFL. — ESPN Research

Bold prediction: Raiders RB Ashton Jeanty will report a season-low variety of dashing makes an attempt (beneath 19), and Mike Washington Jr. will report a season excessive (above seven). Jeanty has recorded minus-15 rush yards over anticipated this season, per NFL Next Gen Stats. Washington is at plus-33. — Walder

Why you must watch this sport: A divisional sport with undefeated groups. Plus, a house sport for Las Vegas towards the hated Chiefs — and the primary sport towards them within the Kubiak period. TE Brock Bowers is the brand new Travis Kelce. This is the sport of the week. — Solak

Injuries: Chiefs | Raiders

Fantasy nugget: Kelce has been dependable this season, scoring no less than 10 fantasy factors in three straight video games, together with a 25.1-point efficiency on 11 targets in Week 2. He now faces a Raiders protection that has given up the third-most fantasy factors per sport to TEs. Kelce has additionally averaged 14.4 fantasy factors per sport over his previous 10 conferences with Las Vegas. See Week 4 rankings. — Moody

Betting perception: Last week, the Chiefs ended a six-game ATS shedding streak on the highway. Walker can maintain them rolling towards a Raiders protection giving up 4.5 yards per carry. That ought to give Mahomes higher passing conditions and probabilities to assault off play-action. Las Vegas struggles to run, and Kansas City hardly ever commits turnovers, which threatens the Raiders’ unbeaten begin. Read more. — Maldonado

Maldonado’s decide: Chiefs 27, Raiders 20
Moody’s decide: Chiefs 30, Raiders 24
Walder’s decide: Raiders 24, Chiefs 22
FPI prediction: KC, 70% (by a median of 5.5 factors)

Matchup must-reads: Chiefs LT Simmons recovering from bulging disc, Reid says … Chiefs’ play-action plan working perfectly for Mahomes, offense so far

8:20 p.m. ET | NBC | DET -3.5 (51.5 O/U)

What we’re listening to on the Lions: RB Jahmyr Gibbs will likely be dealing with his former Alabama teammate, Panthers QB Bryce Young, for the primary time of his profession. When the Lions beat the Panthers in Week 5 of their rookie seasons on Oct. 8, 2023, Gibbs was out due to a hamstring damage however is now wanting ahead to seeing his previous pal on the sector. “I’ve always been rooting for him,” Gibbs mentioned of Young. “I know what he can do. I know what he’s capable of. I told them, ‘I mean, he’s like that. Don’t be surprised if he starts carving y’all up’ but our defense is right. We’re gonna hoop. So, I’m not really worried about that too much.” — Eric Woodyard

What we’re listening to on the Panthers: The Panthers, down their beginning CB duo of Jaycee Horn (quad) and Mike Jackson (groin), will put loads on the plate of 2026 fourth-round decide Will Lee III on Sunday. Coach Dave Canales says there is not any technique to substitute Horn, however he needs the opposite CBs to easily do their job. Lee mentioned one of the best recommendation he has acquired from Horn is to have “that confidence in yourself and the ‘next play’ mentality” when a receiver makes a catch. According to NFL Next Gen Stats, Lee has allowed a catch on eight of 16 targets for team-high 117 yards within the first three video games. — Mike Kaye

Stat to know: The Lions have given up an NFL-worst 31.7 factors per sport this season. — ESPN Research

Bold prediction: Panthers TE Darren Waller will catch a landing. The Lions are permitting targets to opposing TEs 27% of the time, second most within the NFL and most amongst groups that have not confronted the Raiders’ Brock Bowers. Without Brian Branch (Achilles) and Kerby Joseph (knee), it is affordable to anticipate that pattern to proceed and Waller may very well be the beneficiary. — Walder

Why you must watch this sport: The Panthers are overwhelmed up in all places. With each beginning CBs out towards the Lions’ passing assault … and with supersized WR Tetairoa McMillan lining up towards the Lions’ poor defensive backfield … 60 whole factors? 70? — Solak

Injuries: Lions | Panthers

Fantasy nugget: Young has scored no less than 24 fantasy factors in two of his three video games this season. He now faces a Lions protection that has given up essentially the most fantasy factors per sport to QBs. That matchup additionally advantages McMillan, with Detroit giving up the third-most fantasy factors per sport to WRs. See Week 4 rankings. — Moody

Betting perception: The Lions are 13-3 ATS as highway favorites since 2023. Gibbs will get a Carolina protection struggling to cease the run, and accidents to each beginning corners give Jared Goff extra openings. Detroit’s go rush can assault Carolina’s depleted offensive line. Young may discover some performs, however Detroit has the higher setup to tug away. Read more. — Maldonado

Maldonado’s decide: Lions 31, Panthers 24
Moody’s decide: Lions 31, Panthers 28
Walder’s decide: Lions 34, Panthers 14
FPI prediction: DET, 60.9% (by a median of three factors)

Matchup must-reads: “These are exciting games”: Lions offense leading the way as defense finds footing … What’s level of concern for Panthers’ notable injuries before Week 4? … Lions’ Izien leads list of NFL stars with Africa ties

Monday, 8:15 p.m. ET | ESPN | NO -2.5 (47.5 O/U)

What we’re listening to on the Falcons: Atlanta was anticipated to have a great offensive line, because it has had important continuity with the group. But the Falcons have surprisingly dominated the trenches on each side of the ball regardless of an unheralded entrance seven, one thing the crew hopes will proceed Monday evening towards its greatest rival. The Falcons are third in go rush win charge (61%), sixth in run cease win charge (32%), eleventh in go block win charge (53%) and ninth in run block win charge (74%). — Marc Raimondi

What we’re listening to on the Saints: The Saints will have fun the twentieth anniversary of their return to the Superdome after Hurricane Katrina by recognizing members of the 2006 crew, together with Steve Gleason, who famously blocked a punt to assist the Saints win that sport towards the Falcons. Though many Saints gamers are too younger to do not forget that sport, they mentioned they’ve realized in regards to the significance of it and what Gleason means. “Just imagining what it could have been like for all the people and … the lives lost and … and what it kind of means and what the Saints mean to the city. We wear that on our sleeve for sure,” QB Tyler Shough mentioned. — Katherine Terrell

Stat to know: Falcons RB Bijan Robinson has had three profession primetime video games with 200-plus scrimmage yards, which is tied for essentially the most by any participant for the reason that 1970 merger (alongside Jerry Rice, Shaun Alexander and Derrick Henry). — ESPN Research

Bold prediction: Falcons edge Cameron Thomas will report a sack. Thomas has recorded a fast go rush get off common of 0.76 seconds, per NFL Next Gen Stats. That’s one of the best of his profession, and he already has 1.5 sacks this season. Plus, Shough takes sacks at an above-average charge. — Walder

Why you must watch this sport: This is a crucial calibration sport for the Falcons, who regarded reinvigorated of their short-week win over the Packers with the return of QB Michael Penix Jr. Can they’ve the identical defensive success towards a extra purposeful crew? — Solak

Injuries: Falcons | Saints

Fantasy nugget: Shough is the QB3 in fantasy and has recorded no less than 34 go makes an attempt and 22 fantasy factors in three straight video games. The Falcons have given up the fourth-most passing yards per sport, the sixth-most fantasy factors per sport to WRs and the ninth-most to TEs. The stage is about for Shough, WR Chris Olave and TE Juwan Johnson to have massive performances. See Week 4 rankings. — Moody

Betting perception: Penix is 4-2 ATS as an underdog in his profession. Robinson will get a Saints protection giving up 4.7 yards per carry, giving Atlanta a dependable technique to transfer the ball. Penix’s return additionally makes it tougher to load up towards the run. New Orleans has given up 10 sacks, and Atlanta’s run protection can pressure Shough into harder passing conditions. Read more. — Maldonado

Maldonado’s decide: Falcons 27, Saints 23
Moody’s decide: Saints 34, Falcons 31
Walder’s decide: Saints 19, Falcons 16
FPI prediction: NO, 62.7% (by a median of three.4 factors)

Matchup must-reads: Falcons sign DT Dexter to four-year extension … Saints RB Etienne to sit with hamstring injury