Rosie O’Donnell’s ‘Mounjaro Face’ Transformation Is Undeniable

Hollywood has seen a plethora of celebrities who have totally transformed after taking Ozempic and Mounjaro. Comedian Rosie O’Donnell has lengthy struggled together with her weight, however after lastly reaching the outcomes she’d at all times wished by way of Mounjaro, the mom-of-five seems happier than ever. However, her face tells a extra sophisticated story.

The comic has undergone an plain face transformation lately, ever since his physician prescribed Mounjaro in 2022 to handle his diabetes. As of May 2025, O’Donnell confirmed she was nonetheless utilizing the drug on instagramstating, “I can’t believe this is me now #mounjaro.” Months prior, whereas updating followers about life in Ireland, she talked about she’d been steadily shedding the load. “I’ve lost more weight. I am on Mounjaro for my diabetes, and one of the side effects is you lose weight,” she stated on TikTok. Also, noting “Now that I’m a size large, instead of an XL or a XXL, I find it completely shocking.”

What’s much more surprising is the affect the drug has had on her facial options. Side-by-side images of the actor illustrate a traditional case of what is referred to as “Mounjaro Face” — characterised by distinct quantity loss and diminished elasticity within the face. In O’Donnell’s case, this resulted in free facial pores and skin across the jaw and neck, elevated wrinkles, and sunken cheeks, all contributing to an aged look. Other celebrities seeing related outcomes whereas utilizing Ozempic have fallen victim to “Ozempic Face.”

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From youthful stars like Rebel Wilson and Amy Schumer to older figures corresponding to Oprah and Sharon Osbourne, many have skilled dramatic bodily transformations. Osbourne revealed she by no means stopped shedding pounds after coming off the drug, at one level falling beneath 100 kilos. She and different celebs have bared all about their bad experiences with Ozempic and other GLP-1s; However, O’Donnell seems comfortable to have traded a long time of weight administration points for a thinner look, even when it has resulted in a putting “Mounjaro Face.”

Despite showing a lot older than her present age, she’s by no means expressed remorse. Instead, she has praised the tirzepatide, calling it a ‘lifesaver,’ and famous how nice she feels since shedding the load. In a May 2025 TikTokshe stated, “I feel healthier. I’m sleeping better.”

While some celebs look nice after taking Ozempic or Mounjaro, not everybody has had good outcomes. The adversarial reactions linked to GLP-1s embody constipation, nausea, and vomiting, whereas the aftermath has affected many on a deeper degree. Model Lottie Moss confessed on her podcast Dream On with Lottie Moss that she ended up within the hospital, struggling a seizure after taking Ozempic. Meanwhile, actor Amy Schumer shared she stopped the drug attributable to debilitating nausea on “The Howard Stern Show“