Pirates vs. Cubs odds, prediction, line: 2026 MLB picks for April 10 from proven model

The Chicago Cubs host the Pittsburgh Pirates to begin a three-game collection on Friday afternoon. The Pirates (7-5), who final fell to the Padres on Tuesday, are 3-3 on the street this season. The Cubs (6-6), who’ve gained their final two video games, are 3-3 on their house area in 2026. Chicago starter Shota Imanaga (0-1, 4.50 ERA) has allowed only one earned run in 26 innings towards the Pirates. Carmen Mlodzinski (0-0, 4.00 ERA) will get the beginning for Pittsburgh.

First pitch from Wrigley Field in Chicago is ready for 2:20 pm ET. Chicago is a -143 favourite on the cash line (danger $143 to win $100) within the newest Pirates vs. Cubs odds, whereas the over/below, is 6.5. Before making any Cubs vs. Pirates picks, or MLB predictions, remember to see the Pirates vs. Cubs predictions and betting advice from SportsLine’s proven computer model.

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The SportsLine Projection Model simulates each MLB recreation 10,000 instances. It was a worthwhile 35-29 on top-rated MLB money-line picks final season. It additionally excelled at making house run prop picks in 2025, returning practically 30 models of revenue. Anyone following its MLB betting picks at sportsbooks and on betting sites might have seen sturdy returns.

Now, the model has set its sights on Pirates vs. Cubs and simply locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are a number of MLB odds and betting traces for Pirates vs. Cubs:

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Top Pirates vs. Cubs predictions

After 10,000 simulations of Pirates vs. Cubs, the model is going Over 6.5 mixed runs. The Pirates have performed to the Over in 4 of their final two video games. Three of the Cubs’ final 4 video games have gone over the full. The complete has gone Over in 5 of the Cubs’ final six video games performed on a Friday.

SportsLine’s model tasks greater than 1.8 complete bases for the three Pirates gamers, Oneil Cruz, Brian Reynoldsand Ryan O’Hearn. Chiaco is projected to get simply two gamers over 1.7 complete bases, together with Alex Bregman and Michael Busch. The model tasks 8.7 mixed runs because the Over hits 71% of the time. Get the Pirates vs. Cubs money-line pick at SportsLine.

How to make Pirates vs. Cubs picks

After simulating each pitch of Pirates vs. Cubes 10,000 instances, the model additionally says one aspect of the cash line has all the worth. You can get that pick at SportsLine.

So who wins Pirates vs. Cubs, and which aspect of the cash line has all the worth? Visit SportsLine now to see which side you need to jump on, all from the model that you have crushed your MLB picksand discover out.